Focused on People, Driven by Research

At Biote, our goal is to change the way healthcare is practiced on a global level through hormone optimization and precision and preventative medicine. This approach is deeply rooted in our dedication to scientific and clinical research. To share these developments, we maintain an evolving selection of peer-reviewed white papers and studies.

A Call for More Voices on Hormone Optimization

Originally developed in 1939 for women who underwent radical hysterectomies—and widely used in Europe and Australia—compounded bio-identical hormone pellet therapy is the longest studied form of hormone replacement therapy to date. But more study is needed to build confidence within the scientific community and to increase access, as appropriate, to a broader continuum of options for patients.

Biote seeks to be a leading industry voice for hormone optimization quality and access to information. Human hormones are inherently idiosyncratic, which means that patients need personalized, compounded solutions that offer more flexibility and accessibility than other forms of hormone therapy can offer. We are calling for more clinical research in the often misconstrued and underutilized field of hormone therapy and working to produce our own contributions to this burgeoning field by sharing our results gained from more than 2.5 million pellet insertions in just over a decade. Recognizing a wide gap exists in formal clinical research and education, Biote gathers experiential insights to inform the direction of clinical research and confirm with science the real-world data that patients experience.

Our Research Commitment

Biote is a company dedicated to clinical research for hormone optimization. Learn more about our most recent research projects below.

Breast Cancer Study

  • Published
  • 9-year retrospective review
  • To demonstrate testosterone is breast protective, particularly when delivered by subcutaneous pellet therapy, T and/or Testosterone/ Estradiol delivered subcutaneously as a pellet implant significantly reduced the incidence of breast cancer in pre-and – post-menopausal women.*

Complication Study

  • Published
  • Review of 7 years of data (2012-2019)
  • To identify adverse events for males and females who underwent subcutaneous pellet therapy. The overall complication rate was < 1%.

Validation Study

  • Currently underway
  • Year-long study with 60 participating clinics and 1000+ patients
  • To objectively measure the positive, beneficial effects of testosterone subcutaneous hormone therapy in both pre-and post-menopausal women and hypo-gonadal men.*

Recent Hormone Research

Estrogen, Brain Structure, and Cognition in Postmenopausal Women

Abstract: Declining estrogen levels pre-, during, and post- menopause can affect memory and risk for Alzheimer’s disease. Undesirable side effects of hormone variations emphasize a role for hormone therapy (HT) where possible benefits include a delay in the onset of dementia—yet findings are inconsistent.*

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In the News: Covid Reduces Male Sex Hormone Levels

New Delhi: The fact that Covid-19 has led to deaths of more men than women world-wide could be linked to the ability of SARS-CoV-2 to deplete testosterone levels in their body, a new study has found.*

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The Effect of Hormone Therapy on the Ocular Surface and Intraocular Pressure for Postmenopausal Women*

This study investigates the impact of hormone therapy (HT) on the ocular surface and intraocular pressure in postmenopausal women.*

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Correspondence: Hormone Therapy for Postmenopausal Women*

This correspondence in the letters to the editor section of the New England Journal of Medicine comprises a discussion about the use of compounded therapies to treat the symptoms of menopause.*

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Sub-Cutaneous Hormone Pellet Therapy: The Comprehensive Treatment to Optimize and Balance Hormones Using the Biote Method*

This comprehensive review addresses the current scientific literature and clinical data relating to the efficacy of subcutaneous hormone pellet therapy.*

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Testosterone Insufficiency and Treatment in Women: International Expert Consensus Resolutions*

This review is the product of an expert consensus conference addressing testosterone that occurred in Orlando, Florida, on April 24, 2017, and aims to provide a context as to the potential role of testosterone.*

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Thyroid Disease: A White Paper Monograph*

This white paper addresses the literature related to the treatment of thyroid disease. Special focus is placed on the current literature relating to the suspected cause of hypothyroidism and new research.*

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Testosterone in Men: A Review*

This paper provides a comprehensive review of the history and scientific literature relating to the clinical treatment and diagnosis of testosterone imbalance in men.*

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Breast Cancer and the Hormone Receptor Model: A White Paper Monograph

This white paper examines subcutaneous hormone pellets and the incidence of breast cancer and related mechanisms. The authors examine the use of testosterone pellet therapy in breast cancer survivors.*

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