Focused on People, Driven by Research

At Biote, our goal is to change the way that healthcare is practiced on a global level through hormone optimization and precision and preventative medicine. This approach is deeply rooted in our dedication to scientific and clinical research. To share these developments, we maintain an evolving selection of peer-reviewed white papers and studies.

A Call for More Voices on Hormone Optimization

Originally developed in 1939 for women who underwent radical hysterectomies—and widely used in Europe and Australia—compounded bio-identical hormone pellet therapy is the longest studied form of hormone replacement therapy to date. But more study is needed to build confidence within the scientific community and to increase access, as appropriate, to a broader continuum of options for patients.

Biote seeks to be a leading industry voice for hormone optimization quality, and access. Human hormones are inherently idiosyncratic, which means that patients need personalized, compounded solutions that offer more flexibility than other forms of hormone therapy can offer. We are calling for more clinical research in the poorly understood field of hormone therapy and working to produce our own contributions to this field by sharing our experiences with over 2.5 million pellet insertions. Recognizing that a gap remains to be filled in formal clinical research, Biote is also gathering experiential insights to inform the direction such clinical research might take in the effort to confirm with science that which patient experience is showing us.

Our Research Commitment

Biote is the only hormone optimization company dedicated to clinical research. Learn more about our most recent research projects below.

Breast Cancer Study

  • Published
  • 9-year retrospective review
  • To demonstrate testosterone is breast protective, particularly when delivered – by subcutaneous pellet therapy Testosterone and/or Testosterone/ Estradiol delivered subcutaneously as a pellet implant significantly reduced the incidence of breast cancer in pre-and – post-menopausal women

Complication Study

  • Published
  • Review of 7 years of data – from 2012-2019
  • To identify adverse events for males and females who underwent subcutaneous pellet therapy. The overall complication rate was < 1%

Validation Study

  • Currently underway
  • Year-long study with – 60 participating clinics – and 1000+ patients
  • To objectively measure the positive, beneficial effects of testosterone subcutaneous hormone therapy in both pre-and post-menopausal women and hypo-gonadal men

Recent Hormone Research

Estrogen, brain structure, and cognition in postmenopausal women

Abstract Declining estrogen levels before, during, and after menopause can affect memory and risk for Alzheimer’s disease. Undesirable side effects of hormone variations emphasize a role for hormone therapy (HT) where possible benefits include a delay in the onset of dementia—yet findings are inconsistent.


In the News: Covid Reduces Male Sex Hormone Levels

New Delhi: The fact that Covid-19 has led to deaths of more men than women the world over could be linked to the ability of SARS-CoV-2 to deplete testosterone levels in their body, a new study has found.


The Effect of Hormone Therapy on the Ocular Surface and Intraocular Pressure for Postmenopausal Women

This study investigates the impact of hormone therapy (HT) on the ocular surface and intraocular pressure in postmenopausal women.


Correspondence: Hormone Therapy for Postmenopausal Women

This correspondence in the letters to the editor section of the New England Journal of Medicine comprises a discussion about the use of compounded therapies to treat the symptoms of menopause.


Sub-Cutaneous Hormone Pellet Therapy-The Comprehensive Treatment to Optimize and Balance Hormones Using the Biote Method

This comprehensive review addresses the current scientific literature and clinical data relating to the efficacy of subcutaneous hormone pellet therapy.


Testosterone Insufficiency and Treatment in Women: International Expert Consensus Resolutions

This review is the product of anexpert consensus conference addressing testosterone that occurred in Orlando Florida, on April 24, 2017 and aims to provide a context as to the potential role of testosterone.


Thyroid Disease-A White Paper Monograph

This white paper addresses the literature related to the treatment of thyroid disease. Special focus is placed on the current literature relating to the suspected cause of hypothyroidism and new research.


Testosterone in Men: A Review

This paper provides a comprehensive review of the history and scientific literature relating to the clinical treatment and diagnosis of testosterone imbalance in men.


Breast Cancer and the Hormone Receptor Model-A White Paper Monograph

This white paper examines subcutaneous hormone pellets and the incidence of breast cancer and related mechanisms. The authors examine the use of testosterone pellet therapy in breast cancer survivors.